APCFIX POLNAYA VERSIYA SOFTWARE
Nothing is as easy as it sounds, your new best friend will be Google translation page -> Russian to English.īut if you are determined enough? Then there is hope for you finding some help.Īlexei Kobak this is software developer of APC-Fix, this is diagnostic software for APC UPS. There is some hope at Belarus Minsk, so you to find repair tips and information. On the other hand, additional data that are available from Pfam, such as conservation of family signature residues or conservation of common domain architectures, can increase confidence in a given functional hypothesis.I am happy to report that while APC-Schneider does nothing to help their old customers about UPS repair services in Europe. It must be stressed, however, that homology is no guarantee of functional similarity and transfer of functional annotation based solely on family membership should always be undertaken with caution. The ultimate goal of Pfam is to create a collection of functionally annotated families that is as representative as possible of protein sequence-space, such that our families can be used effectively for both genome-annotation and small-scale protein studies. Ideally, our families should represent functional units, which, when combined in different ways, can generate proteins with unique functions. Members of the same Pfam family are expected to share a common evolutionary history and thus at least some functional aspect. For this reason, a considerable curatorial effort goes into seed alignment generation. To assign domains to proteins which are part of newly sequenced genomes. The quality of the seed alignment is the crucial factor in determining the quality of the Pfam resource, influencing not only all data generated within the database but also the outcome of external searches that use our profile HMMs, e.g. We generate a variety of data downstream, including, among others, a family sequence-conservation logo based on the HMM, a description of domain architectures, where all co-occurrences with other domains are reported, and a species tree summarizing the taxonomic range in the family. In addition to providing matches to UniProtKB, Pfam also provides matches for the NCBI non-redundant database, as well as a collection of metagenomic samples.
APCFIX POLNAYA VERSIYA FULL
Choosing family-specific sequence and domain gathering thresholds (GAs) all sequence regions that score above the GAs are included in the full alignment for the family (GAs are described in detail in a later section of this paper). Pfam-A families are built following what is, in essence, a four-step process: The latter are derived from clusters produced by the ADDA algorithm (), followed by the subtraction of overlapping Pfam-A regions at each release.
Pfam contains two types of families: high quality, manually curated Pfam-A families and automatically generated Pfam-B families. Similarity is detected using the HMMER3 () suite of programs. INTRODUCTION Pfam is a database of protein families, where families are sets of protein regions that share a significant degree of sequence similarity, thereby suggesting homology. Second, we discuss some of the features of domains of unknown function (also known as DUFs), which constitute a rapidly growing class of families within Pfam. 339477, apcfix_polnaia_versiia_skachat_besplatno, 4577.įirst, we explain the definition and use of family-specific, manually curated gathering thresholds. PT Freeport Indonesia (PTFI) currently employs two mining methods, the open-pit mining method in. Our Project Area Forging Cooperation, Ensuring Sustainable Development.
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